Biochem/physiol Actions

Reversible: no

Target IC₅₀: 12 nM against MMP-2

Product does not compete with ATP.

Primary TargetMMP-2

Cell permeable: yes

General description

A cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn²⁺-binding site-targeting inhibitor of MMP-2 (IC₅₀ = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC₅₀ = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC₅₀ >50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Tuccinardi, T., et al. 2006. Bioorg. Med. Chem.14, 4260.Rossello, A., et al. 2004. Bioorg. Med. Chem.12, 2441.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)